Canine idiopathic chronic hepatitis

摘要

Canine idiopathic hepatitis is a common disease, categorized histologically by presence of hepatocellular apoptosis or necrosis, a variable mononuclear or mixed inflammatory cell infiltrate, regeneration and fibrosis.\ud\udClinical signs are vague and non-specific, but there are known breed, age and gender predispositions.\ud\udResults of clinical pathology are non-specific, but usually include elevations in liver enzymes and function impairment; a liver biopsy is required for diagnosis.\ud\udManagement involves around the use of an anti-inflammatory dose of glucocorticoids and other supportive and symptomatic therapies including ursodeoxycholic acid, antioxidants, diuretics, and diet.\ud\udThe prognosis is variable, but there are known prognostic indicators, especially the presence of portal hypertension